BOC-NHCH[CH3(CH2)2]-COOH
N-Boc-L-norvaline
CAS: 53308-95-5
Molecular Formula: C10H19NO4
BOC-NHCH[CH3(CH2)2]-COOH - Names and Identifiers
| Name | N-Boc-L-norvaline |
| Synonyms | Boc-Nva-OH BOC-NVA-OH Boc-NVal-OH BOC-L-NVA-OH Boc-Norvaline BOC-NORVALINE Boc-L-norvaline Boc-Nva-OH·DCHA BOC-L-NORVALINE N-Boc-L-norvaline Boc-Nva-OH (syrup) BOC-NHCH[CH3(CH2)2]-COOH N-(tert-butoxycarbonyl)norvaline (2S)-2-[(tert-butoxycarbonyl)amino]pentanoate N-(1-hydroxy-2-oxohexan-3-yl)carbamic acid tert-butyl ester |
| CAS | 53308-95-5 |
| EINECS | 1533716-785-6 |
| InChI | InChI=1/C10H19NO4/c1-5-6-7(8(12)13)11-9(14)15-10(2,3)4/h7H,5-6H2,1-4H3,(H,11,14)(H,12,13)/p-1/t7-/m0/s1 |
BOC-NHCH[CH3(CH2)2]-COOH - Physico-chemical Properties
| Molecular Formula | C10H19NO4 |
| Molar Mass | 217.26 |
| Density | 1.1518 (rough estimate) |
| Melting Point | 43-47 °C |
| Boling Point | 357.82°C (rough estimate) |
| Flash Point | 164.4°C |
| Vapor Presure | 8.85E-06mmHg at 25°C |
| Appearance | White crystal |
| BRN | 3607582 |
| pKa | 4.02±0.20(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.4500 (estimate) |
| MDL | MFCD00037268 |
BOC-NHCH[CH3(CH2)2]-COOH - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29241990 |
| Hazard Class | IRRITANT |
BOC-NHCH[CH3(CH2)2]-COOH - Introduction
N-Boc-L-norvaline(N-Boc-L-norvaline) is a chiral amino acid with the following properties:
Appearance: White crystalline solid
chemical formula: C9H17NO4
Molecular weight: 203.24g/mol
melting point: 114-117 ℃
N-Boc-L-norvaline are often used as intermediates in organic synthesis. It can be used to synthesize biologically active compounds such as drugs, hormones and biochemical reagents. Due to the existence of chiral structure, N-Boc-L-norvaline plays an important role in drug design and mechanism research.
The common method for preparing N-Boc-L-norvaline is obtained by the protection reaction of L-norvaline. First, L-norvaline is reacted with Boc2O (tert-butoxycarbonyl chloride) to produce N-Boc-L-norvaline under alkaline conditions. After the reaction, the target product is purified by crystallization, solvent extraction and the like.
Regarding safety information, N-Boc-L-norvaline are non-toxic and relatively stable compounds. However, as a chemical substance, it is still necessary to pay attention to the correct operation methods and measures when using it, such as wearing protective equipment and avoiding inhalation or contact with skin, eyes and mucous membranes. Its safety and toxicity need to be evaluated and controlled according to the use environment and specific conditions. Therefore, when using N-Boc-L-norvaline, it is recommended to operate in an experienced chemical laboratory or under the guidance of a professional.
Appearance: White crystalline solid
chemical formula: C9H17NO4
Molecular weight: 203.24g/mol
melting point: 114-117 ℃
N-Boc-L-norvaline are often used as intermediates in organic synthesis. It can be used to synthesize biologically active compounds such as drugs, hormones and biochemical reagents. Due to the existence of chiral structure, N-Boc-L-norvaline plays an important role in drug design and mechanism research.
The common method for preparing N-Boc-L-norvaline is obtained by the protection reaction of L-norvaline. First, L-norvaline is reacted with Boc2O (tert-butoxycarbonyl chloride) to produce N-Boc-L-norvaline under alkaline conditions. After the reaction, the target product is purified by crystallization, solvent extraction and the like.
Regarding safety information, N-Boc-L-norvaline are non-toxic and relatively stable compounds. However, as a chemical substance, it is still necessary to pay attention to the correct operation methods and measures when using it, such as wearing protective equipment and avoiding inhalation or contact with skin, eyes and mucous membranes. Its safety and toxicity need to be evaluated and controlled according to the use environment and specific conditions. Therefore, when using N-Boc-L-norvaline, it is recommended to operate in an experienced chemical laboratory or under the guidance of a professional.
Last Update：2024-04-09 21:01:54
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